
Disponible également...


Resectable gastric cancer remains a major global health challenge, with significant geographic variation in treatment paradigms between Eastern and Western practice. While perioperative chemotherapy has been established as the standard of care in the West, Eastern strategies have traditionally favored...

In recent years, immunotherapy (I-O), following the introduction into clinical practice of several immune checkpoint inhibitors (ICIs), has revolutionized the treatment landscape of many types of cancer. To date, different ICIs, administered either as monotherapy or in combination with other agents,...

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but produced immune-related adverse events across multiple organs. Renal toxicities are uncommon yet significant, and secondary serum amyloid A (AA) amyloidosis has emerged as a rare, underrecognized complication reflecting sustained...

Concurrent chemoradiotherapy (CCRT) is the standard treatment for unresectable esophageal squamous cell carcinoma (ESCC). However, its local control rate and overall survival (OS) gain are limited, resulting in a 5-year survival rate of only 20%. Nevertheless, combined immunotherapy (IT) and chemotherapy...

Accurate prognostic stratification remains a major challenge in colorectal cancer (CRC), as substantial heterogeneity in clinical outcomes persists even within the same pathological stage. While mutation-based circulating tumor DNA (ctDNA) analysis has transformed postoperative risk assessment by enabling...

The therapeutic landscape for metastatic prostate cancer has expanded substantially over the last decade, yet treatment selection remains predominantly driven by clinical parameters rather than validated molecular predictors. This review addresses the urgent need to refine patient stratification by critically...